AustralieFrV1, Main, Exploration, bibRecord, 00A590

Impact of therapeutic immunization on HIV-1 viremia after discontinuation of antiretroviral therapy initiated during acute infection. Commentary

Identifieur interne : 00A590 ( Main/Exploration ); précédent : 00A589; suivant : 00A591

Impact of therapeutic immunization on HIV-1 viremia after discontinuation of antiretroviral therapy initiated during acute infection. Commentary

Auteurs : Rajesh Tim Gandhi [États-Unis] ; Marcus Altfeld [États-Unis] ; Sabine Kinloch-De Loes [Royaume-Uni] ; Bruno Hoen [France] ; Don E. Smith [Australie] ; Brigitte Autran [France] ; Fiona C. Lampe [Royaume-Uni] ; Andrew N. Phillips [Royaume-Uni] ; Li-Ean Goh [Royaume-Uni] ; Jan Andersson [Suède] ; Christos Tsoukas [Canada] ; Anders Sonnerborg [Suède] ; Giuseppe Tambussi [Italie] ; Pierre-Marie Girard [France] ; Mark Bloch [Australie] ; Manuel Battegay [Swaziland] ; Nick Carter [Royaume-Uni] ; Raphaelle El Habib [France] ; Georgia Theofan [États-Unis] ; David A. Cooper [Australie] ; Luc Perrin [Suisse]

Source :

The Journal of infectious diseases [ 0022-1899 ] ; 2005.

RBID : Pascal:05-0375513

Descripteurs français

Pascal (Inist)
- Virus HIV1, Immunisation, Vaccin, Chimiothérapie, Aigu, Microbiologie, Infection, Virémie, Antiviral.
Wicri :
- topic : Vaccin.

English descriptors

KwdEn :
- Acute, Antiviral, Chemotherapy, HIV-1 virus, Immunization, Infection, Microbiology, Vaccine, Viremia.

Abstract

Background. Treatment strategies that would induce durable virological control of human immunodeficiency virus (HIV)-1 in the absence of continued antiretroviral therapy (ART) are highly desirable. Methods. We assessed, in a randomized, double-blind, placebo-controlled trial, whether the addition of therapeutic vaccines (ALVAC-HIV [vCP1452] or ALVAC-HIV and Remune) to ART initiated during acute infection could increase the probability of having a plasma viral load ≤1000 HIV-1 RNA copies/mL 24 weeks after planned discontinuation of ART. Results. All 79 randomized subjects completed the immunization schedule, and 78 discontinued ART with no major safety concerns. After immunization, subjects in the vaccine study arms had significantly increased HIV- 1-specific CD4⁺ and CD8⁺ T cell responses, by interferon-γ enzyme-linked immunospot assay, compared with those in the placebo study arm. Overall, 17.7% of subjects had ≤1000 HIV-1 RNA copies/mL 24 weeks after discontinuation of ART, with no significant difference between the vaccine study arms and the placebo study arm (15.4% vs. 22.2%; difference, -6.8% [95% confidence interval, -26.8% to 10.0%]; P =.54). Conclusion. Therapeutic immunization and ART, compared with ART alone, generated HIV-1-specific cellular immunity but did not lead to better virological control of HIV-1 24 weeks after discontinuation of ART. Our trial design appears to be feasible and safe for testing future immune-boosting strategies.

Affiliations:

Australie, Canada, France, Italie, Royaume-Uni, Suisse, Suède, Swaziland, États-Unis
Angleterre, Auvergne-Rhône-Alpes, Bourgogne-Franche-Comté, Californie, Franche-Comté, Grand Londres, Lombardie, Massachusetts, Nouvelle-Galles du Sud, Rhône-Alpes, Svealand, Île-de-France
Besançon, Boston, Londres, Lyon, Milan, Paris, Stockholm, Sydney

Links toward previous steps (curation, corpus...)

to stream PascalFrancis, to step Corpus: 004810
to stream PascalFrancis, to step Curation: 001893
to stream PascalFrancis, to step Checkpoint: 004555
to stream Main, to step Merge: 00B205
to stream Main, to step Curation: 00A590

Le document en format XML

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<author><name sortKey="Bloch, Mark" sort="Bloch, Mark" uniqKey="Bloch M" first="Mark" last="Bloch">Mark Bloch</name>
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<author><name sortKey="Perrin, Luc" sort="Perrin, Luc" uniqKey="Perrin L" first="Luc" last="Perrin">Luc Perrin</name>
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<sourceDesc><biblStruct><analytic><title xml:lang="en" level="a">Impact of therapeutic immunization on HIV-1 viremia after discontinuation of antiretroviral therapy initiated during acute infection. Commentary</title>
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<author><name sortKey="Lampe, Fiona C" sort="Lampe, Fiona C" uniqKey="Lampe F" first="Fiona C." last="Lampe">Fiona C. Lampe</name>
<affiliation wicri:level="3"><inist:fA14 i1="06"><s1>Department of Primary Care and Population Sciences, Royal Free Centre for HIV Medicine, Royal Free and University College Medical School</s1>
<s2>London</s2>
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<author><name sortKey="Phillips, Andrew N" sort="Phillips, Andrew N" uniqKey="Phillips A" first="Andrew N." last="Phillips">Andrew N. Phillips</name>
<affiliation wicri:level="3"><inist:fA14 i1="06"><s1>Department of Primary Care and Population Sciences, Royal Free Centre for HIV Medicine, Royal Free and University College Medical School</s1>
<s2>London</s2>
<s3>GBR</s3>
<sZ>7 aut.</sZ>
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</placeName>
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<author><name sortKey="Goh, Li Ean" sort="Goh, Li Ean" uniqKey="Goh L" first="Li-Ean" last="Goh">Li-Ean Goh</name>
<affiliation wicri:level="1"><inist:fA14 i1="07"><s1>GlaxoSmithKline Research and Development</s1>
<s2>Greenford</s2>
<s3>GBR</s3>
<sZ>9 aut.</sZ>
<sZ>17 aut.</sZ>
</inist:fA14>
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</affiliation>
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<author><name sortKey="Andersson, Jan" sort="Andersson, Jan" uniqKey="Andersson J" first="Jan" last="Andersson">Jan Andersson</name>
<affiliation wicri:level="3"><inist:fA14 i1="08"><s1>Department of Infectious Diseases, Karolinska University Hospital</s1>
<s2>Stockholm</s2>
<s3>SWE</s3>
<sZ>10 aut.</sZ>
<sZ>12 aut.</sZ>
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<country>Suède</country>
<placeName><settlement type="city">Stockholm</settlement>
<region nuts="2">Svealand</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Tsoukas, Christos" sort="Tsoukas, Christos" uniqKey="Tsoukas C" first="Christos" last="Tsoukas">Christos Tsoukas</name>
<affiliation wicri:level="1"><inist:fA14 i1="09"><s1>Immune Deficiency Treatment Centre, Montreal General Hospital</s1>
<s2>Montreal, Quebec</s2>
<s3>CAN</s3>
<sZ>11 aut.</sZ>
</inist:fA14>
<country>Canada</country>
<wicri:noRegion>Montreal, Quebec</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Sonnerborg, Anders" sort="Sonnerborg, Anders" uniqKey="Sonnerborg A" first="Anders" last="Sonnerborg">Anders Sonnerborg</name>
<affiliation wicri:level="3"><inist:fA14 i1="08"><s1>Department of Infectious Diseases, Karolinska University Hospital</s1>
<s2>Stockholm</s2>
<s3>SWE</s3>
<sZ>10 aut.</sZ>
<sZ>12 aut.</sZ>
</inist:fA14>
<country>Suède</country>
<placeName><settlement type="city">Stockholm</settlement>
<region nuts="2">Svealand</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Tambussi, Giuseppe" sort="Tambussi, Giuseppe" uniqKey="Tambussi G" first="Giuseppe" last="Tambussi">Giuseppe Tambussi</name>
<affiliation wicri:level="3"><inist:fA14 i1="10"><s1>Clinic of Infectious Diseases, San Raffaele Scientific Institute</s1>
<s2>Milan</s2>
<s3>ITA</s3>
<sZ>13 aut.</sZ>
</inist:fA14>
<country>Italie</country>
<placeName><settlement type="city">Milan</settlement>
<region nuts="2">Lombardie</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Girard, Pierre Marie" sort="Girard, Pierre Marie" uniqKey="Girard P" first="Pierre-Marie" last="Girard">Pierre-Marie Girard</name>
<affiliation wicri:level="3"><inist:fA14 i1="11"><s1>Department of Infectious and Tropical Diseases, Rothschild Hospital, Assistance Publique- Hôpitaux de Paris</s1>
<s2>Paris</s2>
<s3>FRA</s3>
<sZ>14 aut.</sZ>
</inist:fA14>
<country>France</country>
<placeName><region type="region">Île-de-France</region>
<region type="old region">Île-de-France</region>
<settlement type="city">Paris</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Bloch, Mark" sort="Bloch, Mark" uniqKey="Bloch M" first="Mark" last="Bloch">Mark Bloch</name>
<affiliation wicri:level="1"><inist:fA14 i1="12"><s1>Holdsworth House General Practice</s1>
<s2>Darlinghurst, New South Wales</s2>
<s3>AUS</s3>
<sZ>15 aut.</sZ>
</inist:fA14>
<country>Australie</country>
<wicri:noRegion>Holdsworth House General Practice</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Battegay, Manuel" sort="Battegay, Manuel" uniqKey="Battegay M" first="Manuel" last="Battegay">Manuel Battegay</name>
<affiliation wicri:level="1"><inist:fA14 i1="13"><s1>Division of Infectious Diseases, Basel University Hospital</s1>
<s2>Basel</s2>
<s3>SWZ</s3>
<sZ>16 aut.</sZ>
</inist:fA14>
<country>Swaziland</country>
<wicri:noRegion>Basel</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Carter, Nick" sort="Carter, Nick" uniqKey="Carter N" first="Nick" last="Carter">Nick Carter</name>
<affiliation wicri:level="1"><inist:fA14 i1="07"><s1>GlaxoSmithKline Research and Development</s1>
<s2>Greenford</s2>
<s3>GBR</s3>
<sZ>9 aut.</sZ>
<sZ>17 aut.</sZ>
</inist:fA14>
<country>Royaume-Uni</country>
<wicri:noRegion>GlaxoSmithKline Research and Development</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="El Habib, Raphaelle" sort="El Habib, Raphaelle" uniqKey="El Habib R" first="Raphaelle" last="El Habib">Raphaelle El Habib</name>
<affiliation wicri:level="3"><inist:fA14 i1="14"><s1>Sanofi pasteur</s1>
<s2>Lyon</s2>
<s3>FRA</s3>
<sZ>18 aut.</sZ>
</inist:fA14>
<country>France</country>
<placeName><region type="region">Auvergne-Rhône-Alpes</region>
<region type="old region">Rhône-Alpes</region>
<settlement type="city">Lyon</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Theofan, Georgia" sort="Theofan, Georgia" uniqKey="Theofan G" first="Georgia" last="Theofan">Georgia Theofan</name>
<affiliation wicri:level="2"><inist:fA14 i1="15"><s1>Immune Response Corporation</s1>
<s2>Carlsbad, California</s2>
<s3>USA</s3>
<sZ>19 aut.</sZ>
</inist:fA14>
<country>États-Unis</country>
<placeName><region type="state">Californie</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Cooper, David A" sort="Cooper, David A" uniqKey="Cooper D" first="David A." last="Cooper">David A. Cooper</name>
<affiliation wicri:level="3"><inist:fA14 i1="04"><s1>National Centre in HIV Epidemiology and Clinical Research, University of New South Wales and St. Vincent's Hospital</s1>
<s2>Sydney</s2>
<s3>AUS</s3>
<sZ>5 aut.</sZ>
<sZ>20 aut.</sZ>
</inist:fA14>
<country>Australie</country>
<placeName><settlement type="city">Sydney</settlement>
<region type="état">Nouvelle-Galles du Sud</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Perrin, Luc" sort="Perrin, Luc" uniqKey="Perrin L" first="Luc" last="Perrin">Luc Perrin</name>
<affiliation wicri:level="1"><inist:fA14 i1="16"><s1>Laboratory of Virology, Division of Infectious Diseases, Geneva University Hospital</s1>
<s2>Geneva</s2>
<s3>CHE</s3>
<sZ>21 aut.</sZ>
</inist:fA14>
<country>Suisse</country>
<wicri:noRegion>Geneva</wicri:noRegion>
</affiliation>
</author>
</analytic>
<series><title level="j" type="main">The Journal of infectious diseases</title>
<title level="j" type="abbreviated">J. infect. dis.</title>
<idno type="ISSN">0022-1899</idno>
<imprint><date when="2005">2005</date>
</imprint>
</series>
</biblStruct>
</sourceDesc>
<seriesStmt><title level="j" type="main">The Journal of infectious diseases</title>
<title level="j" type="abbreviated">J. infect. dis.</title>
<idno type="ISSN">0022-1899</idno>
</seriesStmt>
</fileDesc>
<profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Acute</term>
<term>Antiviral</term>
<term>Chemotherapy</term>
<term>HIV-1 virus</term>
<term>Immunization</term>
<term>Infection</term>
<term>Microbiology</term>
<term>Vaccine</term>
<term>Viremia</term>
</keywords>
<keywords scheme="Pascal" xml:lang="fr"><term>Virus HIV1</term>
<term>Immunisation</term>
<term>Vaccin</term>
<term>Chimiothérapie</term>
<term>Aigu</term>
<term>Microbiologie</term>
<term>Infection</term>
<term>Virémie</term>
<term>Antiviral</term>
</keywords>
<keywords scheme="Wicri" type="topic" xml:lang="fr"><term>Vaccin</term>
</keywords>
</textClass>
</profileDesc>
</teiHeader>
<front><div type="abstract" xml:lang="en">Background. Treatment strategies that would induce durable virological control of human immunodeficiency virus (HIV)-1 in the absence of continued antiretroviral therapy (ART) are highly desirable. Methods. We assessed, in a randomized, double-blind, placebo-controlled trial, whether the addition of therapeutic vaccines (ALVAC-HIV [vCP1452] or ALVAC-HIV and Remune) to ART initiated during acute infection could increase the probability of having a plasma viral load ≤1000 HIV-1 RNA copies/mL 24 weeks after planned discontinuation of ART. Results. All 79 randomized subjects completed the immunization schedule, and 78 discontinued ART with no major safety concerns. After immunization, subjects in the vaccine study arms had significantly increased HIV- 1-specific CD4<sup>+</sup>
 and CD8<sup>+</sup>
 T cell responses, by interferon-γ enzyme-linked immunospot assay, compared with those in the placebo study arm. Overall, 17.7% of subjects had ≤1000 HIV-1 RNA copies/mL 24 weeks after discontinuation of ART, with no significant difference between the vaccine study arms and the placebo study arm (15.4% vs. 22.2%; difference, -6.8% [95% confidence interval, -26.8% to 10.0%]; P =.54). Conclusion. Therapeutic immunization and ART, compared with ART alone, generated HIV-1-specific cellular immunity but did not lead to better virological control of HIV-1 24 weeks after discontinuation of ART. Our trial design appears to be feasible and safe for testing future immune-boosting strategies.</div>
</front>
</TEI>
<affiliations><list><country><li>Australie</li>
<li>Canada</li>
<li>France</li>
<li>Italie</li>
<li>Royaume-Uni</li>
<li>Suisse</li>
<li>Suède</li>
<li>Swaziland</li>
<li>États-Unis</li>
</country>
<region><li>Angleterre</li>
<li>Auvergne-Rhône-Alpes</li>
<li>Bourgogne-Franche-Comté</li>
<li>Californie</li>
<li>Franche-Comté</li>
<li>Grand Londres</li>
<li>Lombardie</li>
<li>Massachusetts</li>
<li>Nouvelle-Galles du Sud</li>
<li>Rhône-Alpes</li>
<li>Svealand</li>
<li>Île-de-France</li>
</region>
<settlement><li>Besançon</li>
<li>Boston</li>
<li>Londres</li>
<li>Lyon</li>
<li>Milan</li>
<li>Paris</li>
<li>Stockholm</li>
<li>Sydney</li>
</settlement>
</list>
<tree><country name="États-Unis"><region name="Massachusetts"><name sortKey="Gandhi, Rajesh Tim" sort="Gandhi, Rajesh Tim" uniqKey="Gandhi R" first="Rajesh Tim" last="Gandhi">Rajesh Tim Gandhi</name>
</region>
<name sortKey="Altfeld, Marcus" sort="Altfeld, Marcus" uniqKey="Altfeld M" first="Marcus" last="Altfeld">Marcus Altfeld</name>
<name sortKey="Theofan, Georgia" sort="Theofan, Georgia" uniqKey="Theofan G" first="Georgia" last="Theofan">Georgia Theofan</name>
</country>
<country name="Royaume-Uni"><region name="Angleterre"><name sortKey="Kinloch De Loes, Sabine" sort="Kinloch De Loes, Sabine" uniqKey="Kinloch De Loes S" first="Sabine" last="Kinloch-De Loes">Sabine Kinloch-De Loes</name>
</region>
<name sortKey="Carter, Nick" sort="Carter, Nick" uniqKey="Carter N" first="Nick" last="Carter">Nick Carter</name>
<name sortKey="Goh, Li Ean" sort="Goh, Li Ean" uniqKey="Goh L" first="Li-Ean" last="Goh">Li-Ean Goh</name>
<name sortKey="Lampe, Fiona C" sort="Lampe, Fiona C" uniqKey="Lampe F" first="Fiona C." last="Lampe">Fiona C. Lampe</name>
<name sortKey="Phillips, Andrew N" sort="Phillips, Andrew N" uniqKey="Phillips A" first="Andrew N." last="Phillips">Andrew N. Phillips</name>
</country>
<country name="France"><region name="Bourgogne-Franche-Comté"><name sortKey="Hoen, Bruno" sort="Hoen, Bruno" uniqKey="Hoen B" first="Bruno" last="Hoen">Bruno Hoen</name>
</region>
<name sortKey="Autran, Brigitte" sort="Autran, Brigitte" uniqKey="Autran B" first="Brigitte" last="Autran">Brigitte Autran</name>
<name sortKey="El Habib, Raphaelle" sort="El Habib, Raphaelle" uniqKey="El Habib R" first="Raphaelle" last="El Habib">Raphaelle El Habib</name>
<name sortKey="Girard, Pierre Marie" sort="Girard, Pierre Marie" uniqKey="Girard P" first="Pierre-Marie" last="Girard">Pierre-Marie Girard</name>
</country>
<country name="Australie"><region name="Nouvelle-Galles du Sud"><name sortKey="Smith, Don E" sort="Smith, Don E" uniqKey="Smith D" first="Don E." last="Smith">Don E. Smith</name>
</region>
<name sortKey="Bloch, Mark" sort="Bloch, Mark" uniqKey="Bloch M" first="Mark" last="Bloch">Mark Bloch</name>
<name sortKey="Cooper, David A" sort="Cooper, David A" uniqKey="Cooper D" first="David A." last="Cooper">David A. Cooper</name>
</country>
<country name="Suède"><region name="Svealand"><name sortKey="Andersson, Jan" sort="Andersson, Jan" uniqKey="Andersson J" first="Jan" last="Andersson">Jan Andersson</name>
</region>
<name sortKey="Sonnerborg, Anders" sort="Sonnerborg, Anders" uniqKey="Sonnerborg A" first="Anders" last="Sonnerborg">Anders Sonnerborg</name>
</country>
<country name="Canada"><noRegion><name sortKey="Tsoukas, Christos" sort="Tsoukas, Christos" uniqKey="Tsoukas C" first="Christos" last="Tsoukas">Christos Tsoukas</name>
</noRegion>
</country>
<country name="Italie"><region name="Lombardie"><name sortKey="Tambussi, Giuseppe" sort="Tambussi, Giuseppe" uniqKey="Tambussi G" first="Giuseppe" last="Tambussi">Giuseppe Tambussi</name>
</region>
</country>
<country name="Swaziland"><noRegion><name sortKey="Battegay, Manuel" sort="Battegay, Manuel" uniqKey="Battegay M" first="Manuel" last="Battegay">Manuel Battegay</name>
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<country name="Suisse"><noRegion><name sortKey="Perrin, Luc" sort="Perrin, Luc" uniqKey="Perrin L" first="Luc" last="Perrin">Luc Perrin</name>
</noRegion>
</country>
</tree>
</affiliations>
</record>

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	Serveur d'exploration sur les relations entre la France et l'Australie
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Impact of therapeutic immunization on HIV-1 viremia after discontinuation of antiretroviral therapy initiated during acute infection. Commentary

Impact of therapeutic immunization on HIV-1 viremia after discontinuation of antiretroviral therapy initiated during acute infection. Commentary

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